Individual differences in the sensitivity of cold allodynia to phentolamine in neuropathic rats.

Abstract

In neuropathic rats sensitive to phentolamine (alpha-adrenoreceptor antagonist, 2 mg/kg, i.p.), prazosin (alpha1-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) significantly attenuated cold allodynia whereas yohimbine (alpha2-adrenoreceptor antagonist, 0.5 mg/kg, i.p.) had no significant effect. In neuropathic rats insensitive to phentolamine, yohimbine significantly exacerbated cold allodynia whereas prazosin had no significant effect. These results suggest that the individual differences in the sensitivity of cold allodynia to phentolamine may be due to the difference in the alpha-adrenoreceptor subtype predominantly involved in cold allodynia.

• Authors: Sun Kwang Kim, Byung-Il Min, Ji Hoon Kim, Byung Gil Hwang, Gi Yong Yoo, Dong Suk Park, Heung Sik Na
• Journal: European journal of pharmacology (Eur J Pharmacol) Vol. 523 Issue 1-3 Pg. 64-6 (Oct 31 2005) ISSN: 0014-2999 [Print] Netherlands
• PMID: 16226740 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Adrenergic alpha-1 Receptor Antagonists
• Adrenergic alpha-2 Receptor Antagonists
• Adrenergic alpha-Antagonists
• Yohimbine
• Prazosin
• Phentolamine

Topics

• Adrenergic alpha-1 Receptor Antagonists
• Adrenergic alpha-2 Receptor Antagonists
• Adrenergic alpha-Antagonists (administration & dosage, pharmacology)
• Animals
• Behavior, Animal (drug effects)
• Cold Temperature
• Disease Models, Animal
• Hyperalgesia (physiopathology, prevention & control)
• Male
• Nociceptors (drug effects)
• Pain (physiopathology, prevention & control)
• Pain Threshold (drug effects)
• Peripheral Nervous System Diseases (drug therapy, physiopathology)
• Phentolamine (administration & dosage, pharmacology)
• Prazosin (administration & dosage, pharmacology)
• Rats
• Rats, Sprague-Dawley
• Spinal Nerves (surgery)
• Time Factors
• Yohimbine (administration & dosage, pharmacology)