Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.

Abstract

We investigated the effects of an Na(+)/H(+) exchanger inhibitor, sabiporide, on excitotoxicity in cultured neuronal cells and in vivo. Sabiporide attenuated glutamate- or NMDA (N-methyl-d-aspartic acid)-induced neuronal cell death. Sabiporide also reduced glutamate or NMDA-induced increase in [Ca(2+)](i). In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo.

• Authors: Hye-Seong Park, Bo Kyung Lee, Sok Park, Seung U Kim, Soo Hwan Lee, Eun Joo Baik, Sunkyung Lee, Kyu Yang Yi, Sung Eun Yoo, Chang-Hyun Moon, Yi-Sook Jung
• Journal: Brain research (Brain Res) Vol. 1061 Issue 1 Pg. 67-71 (Nov 02 2005) ISSN: 0006-8993 [Print] Netherlands
• PMID: 16225853 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Guanidines
• Sodium-Hydrogen Exchangers
• Tetrazolium Salts
• Thiazoles
• Glutamic Acid
• N-Methylaspartate
• thiazolyl blue
• Calcium
• sabiporide

Topics

• Animals
• Brain Infarction (etiology, pathology, prevention & control)
• Brain Ischemia (chemically induced, drug therapy, pathology)
• Calcium (metabolism)
• Cell Death (drug effects)
• Cells, Cultured
• Cerebral Cortex (pathology)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Drug Interactions
• Extracellular Space (drug effects)
• Glutamic Acid (adverse effects)
• Guanidines (pharmacology, therapeutic use)
• Mice
• N-Methylaspartate (adverse effects)
• Neurons (drug effects, pathology)
• Reperfusion (methods)
• Sodium-Hydrogen Exchangers (antagonists & inhibitors)
• Tetrazolium Salts
• Thiazoles