[Sneddon syndrome with anti-mitochondrial type M5 antibodies].

Abstract

INTRODUCTION:

Antimitochondrial type M5 antibodies (AMA-M5) are among the immunological abnormalities associated with Sneddon syndrome.

CASE:

A 45 year-old woman, hospitalized for diplopia and with a 20-year history of obstetrical accidents, internuclear ophthalmoplegia and livedo, was diagnosed with Sneddon syndrome associated with primary antiphospholipid syndrome (APS) aggravated by the presence of AMA-M5.

DISCUSSION:

AMA-M5 are immunological markers of APS to the same extent as antiphospholipid antibodies. This case demonstrates the interest of screening for AMA-M5 in cases of strong clinical suspicion of APS when the anticoagulant lupus test is normal and no anti-cardiolipin, anti-b2 glycoprotein I or antiprothrombin antibodies are found.

• Authors: C Seinturier, B Imbert, D Ponard, C Drouet, J-L Debru
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 34 Issue 14 Pg. 1011-2 (Aug 27 2005) ISSN: 0755-4982 [Print] France
• Vernacular Title: Syndrome de Sneddon avec anticorps anti-mitochondries de type M5.
• PMID: 16225256 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Autoantibodies

Topics

• Antiphospholipid Syndrome (complications, diagnosis, immunology)
• Autoantibodies (immunology)
• Diagnosis, Differential
• Female
• Humans
• Middle Aged
• Mitochondria (immunology)
• Sneddon Syndrome (complications, diagnosis)