Uterine fibroid embolization can still be improved: observations on post-procedure magnetic resonance imaging.

Abstract

PURPOSE:

To evaluate the efficacy and completeness of uterine fibroid embolization (UFE) measured by changes in volume and signal intensity at magnetic resonance imaging (MRI), and to compare with clinical outcome.

MATERIAL AND METHODS:

40 women with symptomatic uterine fibroids underwent bilateral uterine artery embolization. At MRI studies, including post-contrast sequences before and repeatedly after treatment, the uterus and dominant fibroids were evaluated for volume, location, and contrast enhancement. Prior to treatment, all myomas showed significant contrast enhancement. The mean uterine volume was 929 ml. Clinical examinations with emphasis on menorrhagia, pelvic pain, and urinary dysfunction were performed before and 6 and 12 months after treatment.

RESULTS:

UFE was bilaterally successful in 38 patients. After UFE, MRI showed no enhancement of myomas in 30 patients. In 8 patients, post-procedural MRI revealed partially remaining vascularization of fibroids despite angiographically complete embolization of the uterine arteries. On average, uterine volume decreased by 46.2% at 12 months. There was significant improvement of symptoms in the majority of patients, but slightly less improvement in patients with partially remaining vascularization of myomas.

CONCLUSION:

UFE causes significant volume reduction of myomas and clinical improvement. MRI can reveal remaining vascularization in myomas despite angiographically complete embolization of uterine arteries.

• Authors: E J Dorenberg, Z Novakovic, H J Smith, G Hafsahl, J A Jakobsen
• Journal: Acta radiologica (Stockholm, Sweden : 1987) (Acta Radiol) Vol. 46 Issue 5 Pg. 547-53 (Aug 2005) ISSN: 0284-1851 [Print] England
• PMID: 16224935 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Contrast Media

Topics

• Adult
• Contrast Media (administration & dosage)
• Embolization, Therapeutic (methods)
• Female
• Follow-Up Studies
• Humans
• Leiomyoma (therapy)
• Magnetic Resonance Imaging (methods)
• Middle Aged
• Prospective Studies
• Treatment Outcome
• Uterine Neoplasms (therapy)