Fluorescent microscopic study of epithalon binding in maternal and fetal rabbit tissues in health and under conditions of placental insufficiency.

Abstract

Epithalon (regulatory tetrapeptide) labeled with dansil (fluorescent stain) easily penetrates into all tissues and organs of pregnant rabbit females and through the placenta into fetal organs. Incorporation of labeled epithalon in placental tissues is more often observed in fetuses developing under conditions of placental insufficiency than in normal fetuses.

• Authors: E A Lapina, L A Nazarova, O P Petrova, D A Sibarov, L B Zubzhitskaya, N G Pavlova, N N Konstantinova, Ya S Konovalov, I M Kvetnoi, A V Arutyunyan, E I Grigorev
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 139 Issue 5 Pg. 615-8 (May 2005) ISSN: 0007-4888 [Print] United States
• PMID: 16224563 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oligopeptides
• alanyl-glutamyl-aspartyl-glycine

Topics

• Animals
• Female
• Fetus (anatomy & histology, physiology)
• Microscopy, Fluorescence
• Oligopeptides (metabolism)
• Placenta (anatomy & histology)
• Placental Insufficiency (physiopathology)
• Pregnancy
• Protein Binding
• Rabbits
• Uterus (blood supply)