Antitumor agent, physalin F from Physalis angulata L.

Abstract

Physalin F and physalin D were isolated and characterized from the ethanolic extract of the whole plant of Physalis angulata L. (Solanaceae). Systematic fractionation of the ethanolic extract of the plant led to characterization of physalin F from the fraction PAIV-2 as an active ingredient which showed cytotoxicity in vitro by DEA and MTT assays on 8 cancer cell lines, five human cancer cell lines: HA22T(hepatoma), HeLa(cervix uteri), KB(nasopharynx), Colo-205(colon) and Calu-1(lung); and three animal cancer cell lines: H1477(melanoma), Hep-2(laryngeal) and 8401(glioma). It was found that the anti-hepatoma action is the strongest, and the anti-HeLa is the next. Physalin F also had an antitumor effect in vivo against P388 lymphocytic leukemia in mice whereas physalin D was inactive both in vitro and in vivo.

• Authors: H C Chiang, S M Jaw, C F Chen, W S Kan
• Journal: Anticancer research (Anticancer Res) 1992 May-Jun Vol. 12 Issue 3 Pg. 837-43 ISSN: 0250-7005 [Print] Greece
• PMID: 1622143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Lactones
• Plant Extracts
• Secosteroids
• Steroids
• physalin F

Topics

• Antineoplastic Agents, Phytogenic (chemistry, isolation & purification, pharmacology)
• Cell Division (drug effects)
• Cell Line
• Chromatography
• Drug Screening Assays, Antitumor
• HeLa Cells
• Humans
• KB Cells
• Lactones (chemistry, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy (methods)
• Molecular Conformation
• Molecular Structure
• Neoplasms
• Plant Extracts (isolation & purification, pharmacology)
• Plants, Medicinal
• Secosteroids
• Solubility
• Steroids
• Tumor Cells, Cultured