Abstract | BACKGROUND: Prenatal environment has been shown to modify adult blood pressure profile, but the underlying mechanisms are not well understood. The role of renal immune cell infiltration, oxidative stress, and nitric oxide bioavailability in the pathogenesis was investigated. METHODS: RESULTS: During the prehypertensive stage, at 4 weeks of age, the low protein diet pups exhibited an increase in kidney nitrotyrosine content and in number of immune cells, both of which persisted in untreated animals after hypertension was established, at 8 weeks of age. Urine NOx was increased at 4 weeks and unchanged at 8 weeks of age. Both MMF and Tempol treatment prevented the immune cell infiltration, the increase in kidney nitrotyrosine abundance, and the development of hypertension. The effect on blood pressure persisted throughout the 4- to 10-week observation period after discontinuation of the treatments. CONCLUSION: Renal oxidative stress and infiltrating immune cells may play a pathogenetic role in prenatally programmed hypertension. Nitric oxide bioavailability does not appear impaired.
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Authors | Tyrus Stewart, Flavia F Jung, Jennifer Manning, V Matti Vehaskari |
Journal | Kidney international
(Kidney Int)
Vol. 68
Issue 5
Pg. 2180-8
(Nov 2005)
ISSN: 0085-2538 [Print] United States |
PMID | 16221217
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Cyclic N-Oxides
- Immunosuppressive Agents
- Nitrates
- Nitrites
- Spin Labels
- Nitric Oxide
- 3-nitrotyrosine
- Tyrosine
- Mycophenolic Acid
- tempol
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Topics |
- Animals
- Antioxidants
(pharmacology)
- Cell Movement
(immunology)
- Cyclic N-Oxides
(pharmacology)
- Female
- Hypertension, Renal
(drug therapy, immunology, metabolism)
- Immunosuppressive Agents
(pharmacology)
- Kidney
(immunology, metabolism, pathology)
- Leukocytes
(immunology, pathology)
- Male
- Mycophenolic Acid
(analogs & derivatives, pharmacology)
- Nitrates
(metabolism)
- Nitric Oxide
(metabolism)
- Nitrites
(metabolism)
- Oxidative Stress
(drug effects, physiology)
- Pregnancy
- Rats
- Spin Labels
- Tyrosine
(analogs & derivatives, metabolism)
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