Characterization of mannose-binding lectin gene polymorphism among human T-cell lymphotropic virus 1 and 2-infected asymptomatic subjects.

Abstract	The present study investigated the association between mannose-binding lectin (MBL) gene polymorphism and the susceptibility to human T-cell lymphotropic virus (HTLV) infection in a group of 83 HTLV-infected asymptomatic subjects (62 HTLV-1 and 21 HTLV-2) and 99 healthy controls. Detection of MBLA, MBLB, and MBLC was performed by amplifying a fragment of 349 bp (exon 1) and submitting the product to restriction fragment length polymorphism analysis with BanI and MboII endonucleases. Allele MBLD was investigated by sequence-specific primer-polymerase chain reaction. The frequency of MBLA, MBLB, and MBL*D was 63%, 22%, and 15% among seropositive subjects and 70%, 14%, and 16% among healthy controls, respectively. Genotype differences were statistically significant (chi2 = 11.57; p = 0.04); the presence of genotype BB was 9.6% among HTLV-infected patients compared with 1% among controls (chi2 = 7.151; p = 0.019). A significant difference of the genotype frequencies between HTLV-1 and HTLV-2 infections was observed, but this result could be attributed to the number of investigated HTLV-1-infected subjects. The odds ratio to the presence of BB genotype was 10.453 (1.279 < or = IC95% < or = 85.40; p = 0.019). Results reveal a strong association between MBL polymorphism and HTLV infection. Presence of genotype BB may be associated with the susceptibility to HTLV, but further studies, with a larger number of individuals, will be necessary. MBL polymorphism could possibly have an impact on diseases associated with HTLV infection.
Authors	G S Pontes, B Tamegão-Lopes, L F A Machado, V N Azevedo, M O G Ishak, R Ishak, J A R Lemos, A C R Vallinoto
Journal	Human immunology (Hum Immunol) Vol. 66 Issue 8 Pg. 892-6 (Aug 2005) ISSN: 0198-8859 [Print] United States
PMID	16216673 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Mannose-Binding Lectin
Topics	Deltaretrovirus Infections (virology) Genotype Human T-lymphotropic virus 1 (genetics) Human T-lymphotropic virus 2 (genetics) Humans Mannose-Binding Lectin (genetics) Polymorphism, Genetic (genetics)

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