Active telephone surveillance to evaluate adverse events among civilian smallpox vaccine recipients.

Abstract

OBJECTIVE:

Better characterize and monitor adverse events following Dryvax vaccinia vaccination in civilian health care workers and other first responders.

DESIGN:

Telephone interviews to ascertain adverse events experienced.

RESULTS:

Eight hundred twenty-five vaccinees, including 44 in the comparison group, were interviewed. At 10 days, 71.4% reported blisters, 35.1% reported bumps at the vaccination site, 48.5% swelling, 47.3% scab, tiredness/lethargy/fatigue (43.6%), headache (34.2%), lymph node swelling/tenderness (28.5%), muscle pain (23.1%), chills (14.4%), joint pain 11.8%, and fever >100 degrees F (12.5%). The 12.5% reported missing work because of vaccine adverse events. Most adverse events were anticipated and of short duration.

• Authors: Arnulfo A Muralles, Paula Ray, Steven Black, Henry Shinefield, Christine G Casey, Scott Campbell, Robert T Chen
• Journal: Vaccine (Vaccine) Vol. 24 Issue 4 Pg. 476-84 (Jan 23 2006) ISSN: 0264-410X [Print] Netherlands
• PMID: 16216396 (Publication Type: Journal Article)

Chemical References

• Smallpox Vaccine

Topics

• Adverse Drug Reaction Reporting Systems
• Contraindications
• Humans
• Interviews as Topic
• Population Surveillance
• Public Health Practice (standards)
• Smallpox Vaccine (adverse effects)
• Vaccination (adverse effects)