[Efficacy and safety of azosemide in patients with edema and ascites].

Abstract

OBJECTIVE:

To assess the efficacy and safety of azosemide in patients with edema and ascites.

METHODS:

A multicentral, randomized, double-blind, controlled clinical trial was applied. All 223 patients (cardiac edema 92, hepatogenic edema 63, renal edema 68) were randomized to azoesmide and furosemide group, and all patients were treated for 2 weeks. Patients with cardiac or renal edema took azosemide (30 mg/d) or furosemide (20 mg/d); patients with hepatogenic edema took azosemide (60 mg/d) or furosemide (40 mg/d). The dosage were adjusted to azosemide 60 mg/d (cardiac, renal edema), 90 mg (hepatogeic edema); or furosemide 40 mg/d (cardiac, renal edema), 60 mg (hepatogeic edema), if diuretic effects were not obtained at the end of third day.

RESULTS:

At the end of the study, the weight changes were (2.87+/-3.10) kg and (2.81 +/-2.84) kg; the total effective rate of edema lessen was 89.19% and 89.81%; the total effective rate of heart function improvement was 64.44% and 66.66%; the 24 h urine output increased (321.85 +/-669.52) ml and (273.80 +/-645.72) ml for azosemide and furosemide, respectively. The total effective rate of ascites lessen (tested by B-ultrasound) was 89.28% and 86.66%; abdominal girth decreased (5.20 +/-3.58) cm and (5.03 +/-3.74) cm for azosemide and furosemide, respectively. The adverse event rate was 23.01% in azosemide group and 21.01% in furosemide group; the main adverse effects were hypokalemia, hyperuricemia, hypertriglyceridemia and thirsty.

CONCLUSION:

Azosemide could effectively lessen edema, improve heart function and decrease ascitesûit is well tolerated and is particularly useful for the diuretic treatment.

• Authors: Yun Zhang, Xiao-sheng Hu, Jun-zhu Chen, Zong-Gui Wu, Gao-zhong Huang, Yong-lin Hu, Xiao-sheng Huang, Wei-qin Lin, Jing-chuan Zheng
• Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences (Zhejiang Da Xue Xue Bao Yi Xue Ban) Vol. 34 Issue 5 Pg. 459-64 (09 2005) ISSN: 1008-9292 [Print] China
• PMID: 16216060 (Publication Type: English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)

Chemical References

• Diuretics
• Sulfanilamides
• azosemide

Topics

• Adolescent
• Adult
• Aged
• Ascites (drug therapy, etiology)
• Diuretics (adverse effects, therapeutic use)
• Double-Blind Method
• Edema (drug therapy, etiology)
• Edema, Cardiac (drug therapy, etiology)
• Female
• Heart Failure (complications)
• Humans
• Kidney Diseases (complications)
• Liver Cirrhosis (complications)
• Male
• Middle Aged
• Sulfanilamides (adverse effects, therapeutic use)