Abstract | AIMS: METHODS AND RESULTS: One hundred and thirty seven patients were randomized to ablation and antiarrhythmic drug therapy (ablation group) or antiarrhythmic drug therapy alone (control group). In the ablation group, patients underwent cavo-tricuspid and left inferior pulmonary vein (PV)-mitral isthmus ablation plus circumferential PV ablation. The primary end-point of the study was the absence of any recurrence of atrial arrhythmia lasting >30 s in the 1-year follow-up period, after 1-month blanking period. Three (4.4%) major complications were related to ablation: one patient had a stroke during left atrium ablation, another suffered transient phrenic paralysis, and the third had a pericardial effusion which required pericardiocentesis. After 12 months of follow-up, 63/69 (91.3%) control group patients had at least one AF recurrence, whereas 30/68 (44.1%) (P<0.001) ablation group patients had atrial arrhythmia recurrence (four patients had atrial flutter, 26 patients AF). CONCLUSION:
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Authors | Giuseppe Stabile, Emanuele Bertaglia, Gaetano Senatore, Antonio De Simone, Franco Zoppo, Giovanni Donnici, Pietro Turco, Pietro Pascotto, Massimo Fazzari, Dino Franco Vitale |
Journal | European heart journal
(Eur Heart J)
Vol. 27
Issue 2
Pg. 216-21
(Jan 2006)
ISSN: 0195-668X [Print] England |
PMID | 16214831
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Anti-Arrhythmia Agents
(therapeutic use)
- Atrial Fibrillation
(drug therapy, surgery)
- Catheter Ablation
(methods)
- Female
- Humans
- Male
- Middle Aged
- Secondary Prevention
- Survival Analysis
- Treatment Outcome
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