Abstract | OBJECTIVE: METHODS: RESULTS: The overall frequency of overexpression for estrogen receptor beta was 45.8% (138/301). It was detected most frequently in female patients (in 54.3% of 127 tumors vs 39.7% of 174 tumors in men, P = .012). However, there was no estrogen receptor alpha nuclear staining detectable in non-small cell lung cancers. Interestingly, a significant correlation between estrogen receptor beta expression, stage of disease, grade of differentiation, smoking status, vascular invasion, and survival in patients with stage II and III disease was found. By using multivariate analysis of survival among patients with stage II and III disease, estrogen receptor beta overexpression, stage II tumor, well differentiation, nonsmoking status, and lack of vascular invasion were significantly favorable prognostic factors. CONCLUSIONS: The results presented here show for the first time that immunohistochemical expression of estrogen receptor beta can be used as a prognostic indicator in patients with surgically resected stage II and III non-small cell lung cancers. These observations might offer a possibility for hormonal therapy in patients with lung cancer.
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Authors | Chen-Tu Wu, Yih-Leong Chang, Jin-Yuan Shih, Yung-Chie Lee |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 130
Issue 4
Pg. 979-86
(Oct 2005)
ISSN: 1097-685X [Electronic] United States |
PMID | 16214508
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Carcinoma, Non-Small-Cell Lung
(chemistry, metabolism, surgery)
- Estrogen Receptor beta
(analysis, biosynthesis)
- Female
- Humans
- Lung Neoplasms
(chemistry, metabolism, surgery)
- Male
- Middle Aged
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