[Contribution of the endogenous opioid system to regulation of heart resistance to the arrhythmogenic effect of short-term ischemia and reperfusio].

Abstract

Preliminary selective blockade of micro, delta1, delta2, kappa1, and kappa2 opioid receptors proved to have no effect on the incidence of ventricular arrhythmias during a 10-min coronary occlusion and subsequent reperfusion in ketamine-anesthetized rats. We propose that the endogenous opioid system has no considerable role in regulation of heart resistance to the arrhythmogenic effect of short-term local ischemia and subsequent reperfusion.

• Authors: L N Maslov, A Iu Liishmanov, E V Budankova, D L Stakheev, N V Solenkova, E I Barzakh, P R Oeltgen, G J Gross, W S Chang
• Journal: Izvestiia Akademii nauk. Seriia biologicheskaia (Izv Akad Nauk Ser Biol) 2005 Jul-Aug Issue 4 Pg. 453-9 ISSN: 1026-3470 [Print] Russia (Federation)
• PMID: 16212267 (Publication Type: English Abstract, Journal Article)

Chemical References

• Narcotic Antagonists
• Opioid Peptides
• Receptors, Opioid

Topics

• Animals
• Heart Diseases (metabolism)
• Myocardium (metabolism)
• Narcotic Antagonists (administration & dosage)
• Opioid Peptides (metabolism)
• Rats
• Rats, Wistar
• Receptors, Opioid (metabolism)