[Development of the method of magnetic neutron capture therapy of cancer].

Abstract

The method of magnetic neutron capture therapy (MNTC) of cancer can be described as a combination of two methods: the targeted delivery of drugs using magnetic carriers and the proper neutron capture therapy which consists in tumor irradiation with thermal neutrons following the delivery of 10B compounds to the tumor site. Two-component ultradispersed particles containing Fe and C were tested as magnetic adsorbents of boron phenylalanine and borax. The quantities of absorbed borax proved sufficient for high concentration of boron atoms at the tumor site. The kinetics of boron release to saline substantiates the application of Fe-B (10%) ultradispersed particles for efficient MNTC. Both particle types have high magnetization and magnetic homogeneity, can form stable magnetic suspensions, and have low toxicity.

• Authors: A A Kuznetsov, S N Podoĭnitsyn, V I Filippov, L Kh Komissarova
• Journal: Izvestiia Akademii nauk. Seriia biologicheskaia (Izv Akad Nauk Ser Biol) 2005 Jul-Aug Issue 4 Pg. 448-52 ISSN: 1026-3470 [Print] Russia (Federation)
• PMID: 16212266 (Publication Type: English Abstract, Journal Article)

Chemical References

• Boron Compounds

Topics

• Animals
• Boron Compounds (chemical synthesis, toxicity)
• Boron Neutron Capture Therapy (adverse effects, methods)
• Humans
• Male
• Mice
• Mice, Inbred BALB C
• Nanostructures (chemistry, toxicity)
• Neoplasms (pathology, radiotherapy)
• Neutrons (therapeutic use)