Abstract | BACKGROUND: METHODS: We examined 48 patients with reflux esophagitis and 96 control subjects, 89 with gastric cancer. IL-1beta-511C/T genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. RESULTS: The frequency of IL-1beta-511T alleles was significantly higher in reflux esophagitis patients (57.3%) than in controls (41.1%) (P = 0.0215, chi(2) = 5.289). The frequency of IL-1beta-511T/T genotypes was also significantly higher in reflux esophagitis patients (31.3%) than in controls (15.6%). The odds ratio and the 95% confidence interval were 4.000 and 1.393-11.486, respectively. The frequency of IL-1beta-511T/T genotypes was significantly higher in reflux esophagitis patients (31.3%) than in gastric cancer patients (21.4%). The odds ratio and the 95% confidence interval were 2.961 and 1.054-8.316, respectively. CONCLUSIONS: IL-1beta-511T was associated with reflux esophagitis having hyperacidity. Differences of genetic background regarding gastric acid secretion may exist between Japanese and Caucasians.
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Authors | Atsushi Muramatsu, Takeshi Azuma, Tomoyuki Okuda, Satoko Satomi, Masahiro Ohtani, Soshoku Lee, Hiroyuki Suto, Yoshiyuki Ito, Yukinao Yamazaki, Masaru Kuriyama |
Journal | Journal of gastroenterology
(J Gastroenterol)
Vol. 40
Issue 9
Pg. 873-7
(Sep 2005)
ISSN: 0944-1174 [Print] Japan |
PMID | 16211343
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Alleles
- DNA
(genetics)
- Electrophoresis, Polyacrylamide Gel
- Esophagitis, Peptic
(blood, epidemiology, genetics)
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Humans
- Incidence
- Interleukin-1
(blood, genetics)
- Japan
(epidemiology)
- Male
- Middle Aged
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
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