| Abstract | BACKGROUND: Inflammation, a clinical condition observed in patients with chronic kidney disease (CKD), may be related to increased resting energy expenditure (REE). OBJECTIVES: The main objective was to investigate the relation between inflammation and REE in patients with CKD who are not undergoing dialysis. We also aimed to analyze whether a decrease in C-reactive protein (CRP) would result in a reduction in REE. DESIGN: This study enrolled 132 patients with CKD who were not undergoing dialysis, who had creatinine clearance from 5 to 65 mL.min(-1).1.73 m(-2), and who were 53.6 +/- 16 y old; 82 (62.1%) were men. Twenty-nine patients had clinical signs of infection. REE was measured by using indirect calorimetry, and inflammation was evaluated by using high-sensitivity CRP measurement. Patients were divided according to tertiles of CRP with the following intertertile ranges: first tertile, CRP < or = 0.14 mg/dL (n = 43); second tertile, CRP 0.15-0.59 mg/dL (n = 46); and third tertile, CRP > or = 0.60 mg/dL (n = 43). REE was measured before and after treatment in 10 patients who had inflammation or infection. RESULTS: After adjustment for age, sex, and lean body mass, the REE of the third (1395 kcal/d; P = 0.02) and second (1355 kcal/d; P = 0.04) tertiles was significantly higher than that of the first tertile (1286 kcal/d). In the multiple linear regression analysis (n = 132), the independent determinants of REE were lean body mass, CRP, and age (R2 = 0.55). After treatment of infection in a subgroup of 10 patients, it was observed that a significant reduction in CRP concentration was accompanied by a significant reduction of 174 +/- 165 kcal that accounted for 13% of the initial REE. CONCLUSION: This study showed that inflammation is associated with increased REE in patients with CKD. |
| Authors | Simone Utaka, Carla M Avesani, Sergio A Draibe, Maria A Kamimura, Solange Andreoni, Lilian Cuppari
(Affiliation: Nutrition Program, Federal University of São Paulo, São Paulo, Brazil.)
|
| Journal | The American journal of clinical nutrition
(Am J Clin Nutr)
Vol. 82
Issue 4
Pg. 801-5
(Oct 2005)
ISSN: 0002-9165 United States |
| PMID | 16210709
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Creatinine
- C-Reactive Protein
|
| Topics |
- Anthropometry
- Basal Metabolism
(physiology)
- Body Composition
- C-Reactive Protein
- Calorimetry, Indirect
(methods)
- Creatinine
(urine)
- Energy Metabolism
(physiology)
- Female
- Glomerular Filtration Rate
- Homeostasis
- Humans
- Inflammation
(metabolism, therapy)
- Kidney Failure, Chronic
(complications, metabolism)
- Linear Models
- Male
- Middle Aged
- Nutrition Assessment
|
