Phelligridimer A, a highly oxygenated and unsaturated 26-membered macrocyclic metabolite with antioxidant activity from the fungus Phellinus igniarius.

Abstract

[structure: see text] A highly oxygenated and unsaturated 26-membered macrocyclic metabolite, phelligridimer A (1), has been isolated from the Chinese medicinal fungus Phellinus igniarius. Its structure was elucidated by spectroscopic methods. A possible biogenesis of 1 mediated by the fungal metabolite hispidin was postulated. Phelligridimer A showed antioxidant activity (IC50 of 10.2 microM) but was inactive to several human cancer cell lines (IC50 > 50 microM) and enzymes PTP1B (IC50 > 25 microM) and thrombin (IC50 > 10 microM).

• Authors: Ying Wang, Su-Juan Wang, Shun-Yan Mo, Shuai Li, Yong-Chun Yang, Jian-Gong Shi
• Journal: Organic letters (Org Lett) Vol. 7 Issue 21 Pg. 4733-6 (Oct 13 2005) ISSN: 1523-7060 [Print] United States
• PMID: 16209522 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antioxidants
• Macrocyclic Compounds
• Pyrones
• phelligridimer A
• Protein Tyrosine Phosphatases

Topics

• Animals
• Antioxidants (isolation & purification, pharmacology)
• Basidiomycota (metabolism)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Humans
• Lipid Peroxidation (drug effects)
• Macrocyclic Compounds (isolation & purification, pharmacology)
• Medicine, Chinese Traditional
• Models, Molecular
• Molecular Structure
• Protein Tyrosine Phosphatases (antagonists & inhibitors)
• Pyrones (isolation & purification, pharmacology)
• Rats