HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

The quality of nifedipine studies used to assess tocolytic efficacy: a systematic review.

AbstractOBJECTIVE:
To assess the quality of studies of nifedipine used to treat spontaneous preterm labor.
DESIGN:
A systematic review of study quality using a novel validity assessment tool, examining method-specific and topic-specific items in the domains of selection, performance and measurement biases.
DATA SOURCES:
Medline (1996-2003), EMBASE (1996-2003), BIOSIS (1993-2003), Current Contents (1995-2003), DERWENT DRUGFILE (1983-2003), Cochrane Database of Systematic Reviews. Bibliographies of existing meta-analyses and systematic reviews of nifedipine as a tocolytic.
METHODS OF STUDY SELECTION:
Forty-five studies evaluating the effectiveness of nifedipine were identified.
DATA EXTRACTION:
Each study was assessed for 40 method-specific and topic-specific items of quality in duplicate using piloted data extraction forms. Disagreements between assessors were settled by consensus/arbitration.
DATA SYNTHESIS:
Very few of the studies complied with adequacy criteria of quality for either method-specific or topic-specific items. There was no improvement in quality over time. The quality of method-specific items was significantly poorer when compared with topic-specific items of quality overall (P<0.0001) and in the domains of selection bias (P<0.0001) and performance bias (P<0.0001).
CONCLUSION:
Studies of the effectiveness of nifedipine as a tocolytic are of poorer quality with respect to method-specific items than topic-specific items. These deficiencies should be highlighted in meta-analyses or systematic reviews which measure efficacy and should influence the generation of guideline statements or recommendations for the use of nifedipine as a tocolytic. A large randomized trial fulfilling the quality items is necessary to assess the real efficacy of nifedipine in preterm labor.
AuthorsRonnie F Lamont, Khalid S Khan, Bryan Beattie, Luis Cabero Roura, Gian Carlo Di Renzo, Joachim W Dudenhausen, Hanns Helmer, Jens Svare, Herman P van Geijn,
JournalJournal of perinatal medicine (J Perinat Med) Vol. 33 Issue 4 Pg. 287-95 ( 2005) ISSN: 0300-5577 [Print] Germany
PMID16207113 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Tocolytic Agents
  • Nifedipine
Topics
  • Female
  • Humans
  • Nifedipine (therapeutic use)
  • Obstetric Labor, Premature (prevention & control)
  • Pregnancy
  • Publications (standards)
  • Randomized Controlled Trials as Topic (standards)
  • Tocolytic Agents (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: