Abstract | OBJECTIVE: METHODS: From June to October 2004, animal models of ONFH defect were established in 45 New Zealand rabbits. They were divided into 3 groups randomly: In group A, as the control group, defect was not filled with any implants; In group B with nHAC; In group C with nHAC+MSC. Imaging and histological observation were made 4, 8, 12 weeks after operation. RESULTS: group C had a better osteogenesis ability than group B and group A. group B had a better osteogenesis ability than group A. Obvious new bones and osteogenesis were observed in group C 4 weeks after operation. The defect areas in group C were almost repaired 12 weeks after operation. CONCLUSION: nHAC has a better effect of osteo-conduction and it is a superior material for repairing bone defect of ONFH and of great value in treating ONFH when compounded with MSCs.
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Authors | Wei Sun, Zirong Li, Zhencai Shi, Nianfei Zhang, Yan Li, Fuzhai Cui |
Journal | Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery
(Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi)
Vol. 19
Issue 9
Pg. 703-6
(Sep 2005)
ISSN: 1002-1892 [Print] China |
PMID | 16206756
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bone Substitutes
- nano-hydroxyapatite-collagen
- Collagen
- Durapatite
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Topics |
- Animals
- Bone Marrow Transplantation
- Bone Substitutes
- Cells, Cultured
- Collagen
- Disease Models, Animal
- Durapatite
- Feasibility Studies
- Female
- Femur Head Necrosis
(pathology, surgery)
- Guided Tissue Regeneration
- Male
- Mesenchymal Stem Cell Transplantation
- Rabbits
- Random Allocation
- Tissue Engineering
(methods)
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