[Efficacy of chondroitin sulphate in the treatment of elderly patients with gonarthrosis and coxarthrosis].

Abstract

AIM:

To study chondroitin sulphate (CS) efficacy, tolerance and response duration in elderly patients with osteoarthrosis (OA) with consideration of OA duration and stage.

MATERIAL AND METHODS:

A total of 97 patients aged 65-85 years with stage II-IV OA by Kellgren-Lawrence received CS treatment. The treatment efficacy was assessed by functional Lecken's index, pain intensity at walking and rest, general functional condition, need in nonsteroid anti-inflammatory (NSAI) drugs. Standardization was achieved with visual analogue scale (VAS).

RESULTS:

Positive effects (pain relief, better functional parameters, lower intake of NSAI drugs) were more pronounced and stable in patients with OA stage 1 and 2. In OA of stage 3 and 4, a beneficial effect of a 6-month CS course was unstable. Side effects were at the level of mean statistics.

CONCLUSION:

CS (structum) is recommended for treatment of OA stage 1-4 by Kellgren-Lawrence. Duration of the treatment depends on severity of x-ray symptoms of the disease.

• Authors: L B Lazebnik, V N Drozdov
• Journal: Terapevticheskii arkhiv (Ter Arkh) Vol. 77 Issue 8 Pg. 64-9 ( 2005) ISSN: 0040-3660 [Print] Russia (Federation)
• PMID: 16206609 (Publication Type: Clinical Trial, English Abstract, Journal Article)

Chemical References

• Chondroitin Sulfates

Topics

• Aged
• Aged, 80 and over
• Chondroitin Sulfates (therapeutic use)
• Female
• Humans
• Male
• Osteoarthritis, Hip (complications, drug therapy, physiopathology)
• Osteoarthritis, Knee (complications, drug therapy, physiopathology)
• Severity of Illness Index