Lack of association of histamine-N-methyltransferase (HNMT) polymorphisms with asthma in the Indian population.

Abstract

Histamine plays a major role in allergic disorders, including asthma. A major pathway of histamine biotransformation in the lungs is mediated by histamine N-methyltransferase (HNMT). We investigated the association of a functional SNP C314T; a SNP A929G, a (CA)n repeat in intron 5, and a novel (CA)n repeat (BV677277), 7.5 kb downstream of the HNMT gene with asthma and its associated traits such as total serum IgE levels in a case-control as well as in a family-based study design. In contrast to a previous study, no association was observed for the polymorphisms investigated with asthma (P>0.05). When haplotypes were constructed for these loci and compared, no significant difference was observed in the distribution between cases and controls. In the family-based design, no biased transmission was observed for any of the polymorphisms and haplotypes with asthma using the additive model of inheritance in family-based association test (FBAT). Thus, consistent with the case-control findings, the polymorphisms and haplotypes in the HNMT gene are not associated with asthma in the Indian population.

• Authors: Shilpy Sharma, Deepti Mann, Tej Pratap Singh, Balaram Ghosh
• Journal: Journal of human genetics (J Hum Genet) Vol. 50 Issue 12 Pg. 611-7 ( 2005) ISSN: 1434-5161 [Print] England
• PMID: 16205835 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Immunoglobulin E
• Histamine N-Methyltransferase

Topics

• Adolescent
• Adult
• Asthma (epidemiology, genetics, immunology)
• Case-Control Studies
• Child
• Child, Preschool
• Female
• Gene Frequency
• Genetic Predisposition to Disease
• Haplotypes
• Histamine N-Methyltransferase (genetics)
• Humans
• Immunoglobulin E (blood)
• India (epidemiology)
• Male
• Polymorphism, Genetic