Cytotoxic limonoids from Brazilian Melia azedarach.

Abstract

Three new C-seco limonoids (1-3) and one new tetracyclic limonoid (4) were isolated from a methanol extract of the ripe fruits of Melia azedarach collected in Curitiba, Brazil, and their structures were elucidated by spectroscopic data analysis and comparison of spectral data with those of the previously known compounds. Among the limonoids isolated in the present study, compounds 3 and 4 exhibited significant inhibitory activity against HeLa S3 cancer cells, whereas 1 and 2 showed weak cytotoxicity.

• Authors: Honglei Zhou, Atsuko Hamazaki, Jose Domingos Fontana, Hironobu Takahashi, Carolina Bueno Wandscheer, Yoshiyasu Fukuyama
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 53 Issue 10 Pg. 1362-5 (Oct 2005) ISSN: 0009-2363 [Print] Japan
• PMID: 16205005 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Limonins

Topics

• Brazil
• Cell Proliferation (drug effects)
• Drug Screening Assays, Antitumor
• Fruit (chemistry)
• HeLa Cells
• Humans
• Limonins (chemistry, isolation & purification, pharmacology)
• Magnetic Resonance Spectroscopy (methods, standards)
• Melia azedarach (chemistry)
• Molecular Conformation
• Reference Standards