Abstract | BACKGROUND: METHODS AND RESULTS: The case group included 3657 patients with myocardial infarction, and the control group comprised 1211 individuals with angiographically normal coronary arteries and without signs or symptoms of myocardial infarction. TaqMan assays were used for the determination of genotypes. Genotype distributions of the -397T/C and -351A/G polymorphisms were not significantly different between the control and patient groups (P> or =0.85). The frequencies of haplotypes defined by the -397T/C and -351A/G polymorphisms were similar in the control group and the patient group (P=0.42). In addition, the distributions of haplotype-defined genotypes (diplotypes) were not significantly different between the control group and the patient group (P=0.81). Separate analyses in women and men did not reveal sex-related associations of specific genotypes or haplotypes of the polymorphisms with myocardial infarction (P> or =0.25). CONCLUSIONS: The results indicate that the -397T/C and -351A/G polymorphisms of ESR1 or haplotypes based on these polymorphisms are not associated with myocardial infarction in a white population.
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Authors | Werner Koch, Petra Hoppmann, Arne Pfeufer, Jakob C Mueller, Albert Schömig, Adnan Kastrati |
Journal | Circulation
(Circulation)
Vol. 112
Issue 14
Pg. 2138-42
(Oct 04 2005)
ISSN: 1524-4539 [Electronic] United States |
PMID | 16203927
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- DNA Primers
- Estrogen Receptor alpha
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Topics |
- Aged
- DNA Primers
- Disease Susceptibility
- Estrogen Receptor alpha
(genetics)
- Europe
(ethnology)
- Female
- Genotype
- Germany
(epidemiology)
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(epidemiology, genetics)
- Polymorphism, Single Nucleotide
- Reference Values
- Restriction Mapping
- Sequence Deletion
- Smoking
- White People
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