Clinical inquiries. What treatments prevent miscarriage after recurrent pregnancy loss?

Abstract

Progesterone produces a small but significant decrease in miscarriage among pregnant women with 3 or more unexplained pregnancy losses (strength of recommendation [SOR]: A, based on a meta-analysis of 3 small randomized controlled trials [RCTs] with wide confidence intervals). Human chorionic gonadotropin (HCG) reduces the rate of recurrent pregnancy loss among women with 2 or more unexplained pregnancy losses (SOR: B, based on a meta-analysis of 4 RCTs with significant methodologic weaknesses). Four types of immunotherapy are ineffective for preventing miscarriage (SOR: A, based on RCTs and systematic reviews of RCTs). Aspirin therapy is ineffective for preventing recurrent miscarriage for women who do not have an autoimmune explanation for previous pregnancy losses (SOR: A, based on RCTs).

• Authors: Matt Price, Gary Kelsberg, Sarah Safranek, Beth Damitz
• Journal: The Journal of family practice (J Fam Pract) Vol. 54 Issue 10 Pg. 892, 894 (Oct 2005) ISSN: 0094-3509 [Print] United States
• PMID: 16202378 (Publication Type: Journal Article, Review)

Chemical References

• Progesterone

Topics

• Abortion, Habitual (prevention & control)
• Clinical Trials as Topic
• Evidence-Based Medicine
• Female
• Humans
• Pregnancy
• Pregnancy Outcome
• Progesterone (therapeutic use)
• Secondary Prevention