[Effect of levonorgestrel-releasing intrauterine system in the treatment of adenomyosis].

To assess the clinical efficacy of levonorgestrel-releasing intrauterine system (LNG-IUS) in the treatment of adenomyosis.
Forty-two patients with adenomyosis diagnosed by clinical symptoms, MRI, laparoscopy and/or chromatic colour type-B ultrasound were treated with LNG-IUS, and the menstrual blood volume, severity of dysmenorrhea and uterine volume were observed three months later.
After 3 month treatment of LNG-IUS, the menstrual blood volume reduced significantly to (27 +/- 11)% of that before treatment. The uterine volume was decreased from (143 +/- 33) cm(3) to (115 +/- 22) cm(3) (P < 0.05). Dysmenorrhea was completely relieved or significantly alleviated. Hemoglobin recovered to (124 +/- 8) g/L (P < 0.05) in 20 patients with anemia.
LNG-IUS is an effective and safe method in the short-term treatment of adenomyosis.
AuthorsShu-ming He, Ming-xiu Wei, Yan-hua Han, Li-hong He
JournalZhonghua fu chan ke za zhi (Zhonghua Fu Chan Ke Za Zhi) Vol. 40 Issue 8 Pg. 536-8 (Aug 2005) ISSN: 0529-567X [Print] China
PMID16202292 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Levonorgestrel
  • Adult
  • Endometriosis (therapy)
  • Female
  • Humans
  • Intrauterine Devices
  • Intrauterine Devices, Medicated
  • Levonorgestrel (pharmacokinetics, pharmacology, therapeutic use)
  • Treatment Outcome
  • Uterus (drug effects, metabolism)

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