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[Study on the association among total immunoglobulin E and eosinophil in nasal polyp].

AbstractOBJECTIVE:
To explore the expression of total immunoglobulin E(IgE) and eosinophil in nasal polyp and their roles in the pathogenesis of nasal polyp.
METHOD:
Thirty eight patients with nasal polyp and 15 control cases were chosen. All samples were stained with Chromotrope 2R histochemical and SP immunohistochemical method separately to examine eosinophil and total IgE+ cells in nasal polyp.
RESULT:
(1) The level of total IgE and eosinophil in nasal polyp was all significantly higher than that in normal control specimens (P < 0.01). (2) The positive correlation of total IgE and eosinophil was significant (r = 0.843, P < 0.01).
CONCLUSION:
Nasal polyp is a disease characterized by eosinophils infiltration. Type I allergic reaction mediated by IgE assemble and activate eosinophils which may play an important role in the infiltration pathogenesis of nasal polyp.
AuthorsShenghua Zhu, Xuemei Luo
JournalLin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology (Lin Chuang Er Bi Yan Hou Ke Za Zhi) Vol. 19 Issue 13 Pg. 602-4 (Jul 2005) China
PMID16200833 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Immunoglobulin E
Topics
  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Eosinophils (immunology, metabolism)
  • Female
  • Humans
  • Immunoglobulin E (immunology, metabolism)
  • Male
  • Middle Aged
  • Nasal Mucosa (immunology, metabolism)
  • Nasal Polyps (immunology, metabolism, pathology)
  • Young Adult

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