Abstract | OBJECTIVE: While both thalamic abnormalities and dopaminergic dysregulation have been separately implicated in the pathophysiology of schizophrenia, little is known about the possible dysfunction of molecules associated with dopaminergic neurotransmission in the thalamus in this illness. In this study, the authors studied this question by measuring in postmortem brain the expression of molecules associated with dopaminergic neurotransmission. METHOD: RESULTS: CONCLUSIONS: These data indicate that there are dopaminergic abnormalities in the thalamus in schizophrenia but that they are at the level of intracellular integration of dopamine signaling with other neurotransmitter systems, likely including glutamate, in thalamic neurons.
|
Authors | Sarah M Clinton, Hisham M Ibrahim, Kirk A Frey, Kenneth L Davis, Vahram Haroutunian, James H Meador-Woodruff |
Journal | The American journal of psychiatry
(Am J Psychiatry)
Vol. 162
Issue 10
Pg. 1859-71
(Oct 2005)
ISSN: 0002-953X [Print] United States |
PMID | 16199832
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Dopamine and cAMP-Regulated Phosphoprotein 32
- Membrane Proteins
- Microfilament Proteins
- Nerve Tissue Proteins
- PPP1R1B protein, human
- RNA, Messenger
- Receptors, Dopamine
- SLC18A2 protein, human
- Vesicular Monoamine Transport Proteins
- calcyon
- neurabin
- Dopamine
|
Topics |
- Aged
- Aged, 80 and over
- Autoradiography
- Dopamine
(metabolism, physiology)
- Dopamine and cAMP-Regulated Phosphoprotein 32
(metabolism)
- Female
- Humans
- Male
- Membrane Proteins
(metabolism, physiology)
- Microfilament Proteins
(metabolism, physiology)
- Middle Aged
- Nerve Tissue Proteins
(metabolism, physiology)
- RNA, Messenger
(metabolism)
- Receptors, Dopamine
(metabolism, physiology)
- Schizophrenia
(metabolism, physiopathology)
- Synaptic Transmission
(physiology)
- Thalamic Nuclei
(metabolism, physiopathology)
- Tissue Distribution
- Vesicular Monoamine Transport Proteins
(metabolism)
|