| Abstract | Subcorneal pustular dermatosis (SCPD) is an uncommon disorder, characterized by a chronic relapsing vesiculopustular eruption, mainly involving the trunk and intertriginous areas, and usually seen in women > 40 years old. Various therapies have been reported to be effective in treating SCPD, such as dapsone, systemic glucocorticoids, acitretin, etretinate, infliximab and phototherapy. We report a case of a 54-year-old woman affected by SCPD who after failure of different therapies showed a dramatic but only temporary improvement of her disease during a cycle of therapy with infliximab. In addition, an array of cytokines was simultaneously measured in suction blister fluids obtained from involved or uninvolved skin at various time intervals during the first 12 weeks of observation. |
| Authors | C Bonifati, E Trento, P Cordiali Fei, L Muscardin, A Amantea, M Carducci
(Affiliation: Department of Dermatology, Institute S. Gallicano, Rome, Italy. bonifaticlaudio at tin.it)
|
| Journal | Clinical and experimental dermatology
(Clin Exp Dermatol)
Vol. 30
Issue 6
Pg. 662-5
(Nov 2005)
ISSN: 0307-6938 England |
| PMID | 16197383
(Publication Type: Case Reports, Journal Article)
|
| Chemical References |
- Antibodies, Monoclonal
- Cytokines
- Dermatologic Agents
- infliximab
|
| Topics |
- Antibodies, Monoclonal
(therapeutic use)
- Blister
(metabolism)
- Body Fluids
(metabolism)
- Cytokines
(metabolism)
- Dermatologic Agents
(therapeutic use)
- Female
- Humans
- Middle Aged
- Skin Diseases, Vesiculobullous
(drug therapy, pathology)
|
