[Antiinflammatory and antiulcer effect of oxymethyluracil].

Abstract

Enteral administration of oxymethyluracil in non-inbred albino rats decreased the inflammatory reaction to histamine, serotonin, bradykinin, carrageenan and trypsin, (being similar to voltaren) and reduced granulomatous inflammation, but influenced the proliferation to a lower extent than did voltaren. In contrast to voltarcen, oxymethyluracil also exhibited gastroprotective antiulcer properties.

• Authors: D N Lazareva, V A Davydova
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2005 Jul-Aug Vol. 68 Issue 4 Pg. 53-5 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 16193660 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Antioxidants
• Histamine Agents
• Serotonin Agents
• Vasodilator Agents
• Diclofenac
• Serotonin
• Uracil
• oxymethacil
• Histamine
• Carrageenan
• Trypsin
• Bradykinin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Antioxidants (administration & dosage)
• Bradykinin (toxicity)
• Carrageenan (toxicity)
• Diclofenac (administration & dosage)
• Histamine (toxicity)
• Histamine Agents (toxicity)
• Inflammation (chemically induced, drug therapy)
• Male
• Rats
• Serotonin (toxicity)
• Serotonin Agents (toxicity)
• Trypsin (toxicity)
• Ulcer (chemically induced, drug therapy)
• Uracil (administration & dosage, analogs & derivatives)
• Vasodilator Agents (toxicity)