[Cerebroprotector activity of Rhaponticum carthamoides extract in rats with brain ischemia].

Abstract

Electron microscopy and electrophysiological data reveal pronounced structural and functional disturbances in cerebral cortex of rats with model brain ischemia. A 5-day treatment with a dry extract from Rhaponticum carthamoides (Willd.) Iljin. in a daily dose of 150 mg/kg (p.o.) equivalent to 2.7 mg ecdysterone per kg body weight reduced manifestations of the ischemic damage, improved the structure of neurons, and restored brain activity (EEG parameters).

• Authors: M B Plotnikov, S V Logvinov, N V Pugachenko, M Iu Maslov, O I Aliev, A S Vasil'ev, N I Suslov, A V Potapov
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) 2005 Jul-Aug Vol. 68 Issue 4 Pg. 19-23 ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 16193651 (Publication Type: English Abstract, Journal Article)

Chemical References

• Plant Extracts

Topics

• Animals
• Brain Ischemia (drug therapy, pathology)
• Cerebral Cortex (physiopathology, ultrastructure)
• Female
• Leuzea (chemistry)
• Male
• Neurons (ultrastructure)
• Phytotherapy (methods)
• Plant Extracts (administration & dosage, chemistry)
• Rats
• Rats, Wistar
• Recovery of Function (drug effects)