Abstract | PURPOSE: MATERIALS AND METHODS: Randomized trials of acupuncture-point stimulation by needles, electrical stimulation, magnets, or acupressure were retrieved. Data were provided by investigators of the original trials and pooled using a fixed-effects model. RESULTS: Eleven trials (N = 1,247) were pooled. Overall, acupuncture-point stimulation reduced the proportion of acute vomiting (relative risks [RR] = 0.82; 95% CI, 0.69 to 0.99; P = .04), but not the mean number of acute emetic episodes or acute or delayed nausea severity compared with controls. By modality, stimulation with needles reduced the proportion of acute vomiting (RR = 0.74; 95% CI, 0.58 to 0.94; P = .01), but not acute nausea severity. Electroacupuncture reduced the proportion of acute vomiting (RR = 0.76; 95% CI, 0.60 to 0.97; P = .02), but manual acupuncture did not; delayed symptoms were not reported. Acupressure reduced mean acute nausea severity (standardized mean difference = -0.19; 95% CI, -0.38 to -0.01; P = .03) and most severe acute nausea, but not acute vomiting or delayed symptoms. Noninvasive electrostimulation showed no benefit for any outcome. All trials used concomitant pharmacologic antiemetics, and all, except electroacupuncture trials, used state-of-the-art antiemetics. CONCLUSION:
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Authors | Jeanette Ezzo, Andrew Vickers, Mary Ann Richardson, Claire Allen, Suzanne L Dibble, Brian Issell, Lixing Lao, Michael Pearl, Gilbert Ramirez, Joseph A Roscoe, Joannie Shen, Jane Shivnan, Konrad Streitberger, Imad Treish, Grant Zhang |
Journal | Journal of clinical oncology : official journal of the American Society of Clinical Oncology
(J Clin Oncol)
Vol. 23
Issue 28
Pg. 7188-98
(Oct 01 2005)
ISSN: 0732-183X [Print] United States |
PMID | 16192603
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
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Topics |
- Acupuncture Points
- Acute Disease
- Antineoplastic Agents
(adverse effects)
- Electric Stimulation Therapy
- Humans
- Nausea
(chemically induced, therapy)
- Neoplasms
(drug therapy)
- Randomized Controlled Trials as Topic
- Treatment Outcome
- Vomiting, Anticipatory
(etiology, therapy)
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