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Detection of selenium in generalized and localized argyria: report of four cases with X-ray microanalysis.

Abstract
Electron microscopic and X-ray microanalytic studies were performed on four cases of argyria; one generalized and three localized. Deposition of electron dense granules was predominantly found on elastic fibers and around basal laminas of secretory portions of eccrine glands, although the amount of deposition was much less in the case of generalized argyria. In all four cases, X-ray microanalysis revealed that the depositions consisted mainly of silver, selenium, and sulfur. The importance of selenium in the detoxification of heavy metals was discussed.
AuthorsT Matsumura, M Kumakiri, A Ohkawara, H Himeno, T Numata, R Adachi
JournalThe Journal of dermatology (J Dermatol) Vol. 19 Issue 2 Pg. 87-93 (Feb 1992) ISSN: 0385-2407 [Print] England
PMID1619110 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Silver
  • Sulfur
  • Selenium
Topics
  • Acupuncture Therapy (adverse effects)
  • Adult
  • Aged
  • Argyria (diagnosis, metabolism, pathology)
  • Crowns (adverse effects)
  • Electron Probe Microanalysis (methods)
  • Electroplating
  • Female
  • Gingiva (chemistry, metabolism, pathology, ultrastructure)
  • Gingival Diseases (chemically induced, diagnosis, metabolism, pathology)
  • Humans
  • Male
  • Microscopy, Electron
  • Middle Aged
  • Occupational Diseases (chemically induced, diagnosis, metabolism, pathology)
  • Selenium (chemistry, metabolism)
  • Silver (adverse effects, chemistry, metabolism)
  • Skin (chemistry, metabolism, pathology, ultrastructure)
  • Sulfur (chemistry, metabolism)

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