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[Dynamic expression of VIPR2 in form deprivation myopia].

AbstractOBJECTIVE:
To investigate the dynamic expression and significance of vasoactive intestinal peptide receptor 2 (VIPR2) on retina-choroid-clera in high myopia.
METHODS:
Twenty-one yellow chicks of 1 day old were used in the research. The right eyes were the experimental group, covered continuously for 1 week, 2 weeks and 4 weeks respectively. The left eyes were not covered as the normal control group. Both groups were detected diopter degrees using retinoscopic refraction, determinated eyeball axis using ophthalmology ultra-A, and investigated VIPR2 expression on retina-choroid-sclera in both groups at three stages by SP immunohistochemical staining.
RESULTS:
The experimental eyes changed from hypermetropia at pre-experiment to high myopia during the experiment stages, and the diopter degrees were deeper and eyeball axis was longer along with the period of being covered. Both groups had strong expression of VIPR2 on photoreceptor-outer segment of the retina and choroids. The expression was down-regulated with the time in both groups. Compared with the control group, VIPR2 expression of the experimental group was significantly up-regulated (P < 0.05).
CONCLUSION:
Form deprivation could induce high myopia. The expression of VIPR2 existed on photoreceptor-outer segment of the retina and choroids. VIPR2 may play an important role on the formation and development of myopia.
AuthorsShuang-zhen Liu, Hua Wang, Jing-jing Jiang, Ping-bao Wang, Xiao-ying Wu, Xing-ping Tan, Zhao-hua Xia
JournalZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences (Zhong Nan Da Xue Xue Bao Yi Xue Ban) Vol. 30 Issue 4 Pg. 456-9 (Aug 2005) ISSN: 1672-7347 [Print] China
PMID16190398 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Receptors, Vasoactive Intestinal Peptide, Type II
Topics
  • Animals
  • Animals, Newborn
  • Chickens
  • Choroid (metabolism)
  • Female
  • Male
  • Myopia (etiology, metabolism)
  • Receptors, Vasoactive Intestinal Peptide, Type II (biosynthesis, genetics)
  • Retina (metabolism)

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