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On-line continuous-flow dialysis thermospray tandem mass spectrometry for quantitative screening of drugs in plasma: rogletimide.

Abstract
The application of a continuous-flow dialysis system, consisting of a membrane dialyser and a trace enrichment column, in on-line combination with tandem mass spectrometry via a thermospray interface is described. The method is applied to the quantitation of drugs in complex biological matrices containing macromolecular interferences. The potential of the method is demonstrated by the quantitative analysis of the anti-cancer drug rogletimide in the plasma of patients after treatment.
AuthorsE van Bakergem, R A van der Hoeven, W M Niessen, U R Tjaden, J van der Greef, G K Poon, R McCague
JournalJournal of chromatography (J Chromatogr) Vol. 598 Issue 2 Pg. 189-94 (May 15 1992) Netherlands
PMID1618979 (Publication Type: Journal Article)
Chemical References
  • Aminoglutethimide
  • rogletimide
Topics
  • Aminoglutethimide (analogs & derivatives, blood)
  • Chromatography, Liquid
  • Dialysis
  • Humans
  • Mass Spectrometry (methods)

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