Abstract | RATIONALE AND OBJECTIVES: METHODS: Twelve rabbits were divided into 2 groups ( tumor and inflammation groups). Six rabbits of tumor group were inoculated with VX2 tumor cell suspension, and the 6 rabbits of the inflammation group were inoculated with 10% croton oil in the bone marrow of the right femur. All rabbits were imaged using a clinical MRI system. Signal intensity in the bone marrow of the right femur was measured in each rabbit before and after the intravenous injection of 8 micromol Fe/kg of ferucarbotran. As a control, the signal intensity in the bone marrow of the left femur (the normal, intact femur) was measured in each rabbit. The change in signal intensity of each group was compared statistically. After MRI imaging, the femora were removed, and sections were prepared for microscopic examination. RESULTS: Signal intensity in the right femur of the tumor group did not change after injection, although that of the inflammation group and the control group decreased. In the histologic findings, tumors were widely spread in the right femur of the tumor group. The infiltration of pseudoeosinocytes was induced in the right femur of the inflammation group. CONCLUSIONS:
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Authors | Natsuko Tsuda, Takashi Tsuji, Naoki Kato, Yuko Fukuda, Kumiko Ando, Reiichi Ishikura, Norio Nakao |
Journal | Investigative radiology
(Invest Radiol)
Vol. 40
Issue 10
Pg. 676-81
(Oct 2005)
ISSN: 0020-9996 [Print] United States |
PMID | 16189437
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Dextrans
- Magnetite Nanoparticles
- Oxides
- Iron
- ferumoxides
- Ferrosoferric Oxide
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Topics |
- Animals
- Bone Marrow Neoplasms
(diagnosis, secondary)
- Contrast Media
- Dextrans
- Diagnosis, Differential
- Feasibility Studies
- Femur
(pathology)
- Ferrosoferric Oxide
- Inflammation
(diagnosis)
- Iron
- Magnetite Nanoparticles
- Male
- Osteitis
(diagnosis)
- Oxides
- Rabbits
- Reproducibility of Results
- Sensitivity and Specificity
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