A role for herpesvirus entry mediator as the receptor for herpes simplex virus 1 entry into primary human trabecular meshwork cells.

Abstract

The human eye is an important target for infection with herpes simplex virus 1 (HSV-1). Damage to cells forming the trabeculum of the eye by HSV-1 infection could contribute to the development of glaucoma, a major blinding disease. Primary cultures of human trabecular meshwork cells were used as an in vitro model to demonstrate the ability of HSV-1 to enter into and establish a productive infection of the trabeculum. Blocking of entry by anti-herpesvirus entry mediator (HVEM) antibody implicated HVEM as the major receptor for HSV-1 infection.

• Authors: Vaibhav Tiwari, Christian Clement, Perry M Scanlan, Devanand Kowlessur, Beatrice Y J T Yue, Deepak Shukla
• Journal: Journal of virology (J Virol) Vol. 79 Issue 20 Pg. 13173-9 (Oct 2005) ISSN: 0022-538X [Print] United States
• PMID: 16189018 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cell Adhesion Molecules
• DNA, Viral
• Nectins
• Receptors, Virus
• Viral Envelope Proteins
• glycoprotein D, Human herpesvirus 1
• Sulfotransferases

Topics

• Cell Adhesion Molecules (metabolism)
• Cells, Cultured
• DNA, Viral (genetics)
• Herpes Simplex (virology)
• Herpesvirus 1, Human (chemistry, physiology)
• Humans
• Microscopy, Confocal
• Nectins
• Polymerase Chain Reaction
• Receptors, Virus (metabolism, physiology)
• Sulfotransferases (metabolism)
• Trabecular Meshwork (metabolism, virology)
• Viral Envelope Proteins (metabolism)
• Virus Replication