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The HLA-B7 allele confers susceptibility to breast cancer in Spanish women.

AbstractBACKGROUND:
Several HLA alleles are associated with susceptibility or protection in breast cancer. The particular allele varies depending on the geographical region. A study in a small group of Spanish patients using serological methods found an association with HLA-B7. We undertook a larger study in southern Spain using molecular biology techniques.
METHODS:
Genotype variants of HLA class I and II were typed by PCR-SSP in 132 breast cancer patients and 382 healthy controls.
RESULTS:
The frequency of the HLA-B7 allele was increased in the patients compared to the controls (P=0.0019; 95% confidence interval, 1.337-3.409, relative risk=2.135). Bonferroni correction of the P showed it was still significant (P(c)=0.0285).
CONCLUSIONS:
These results support previous suggestions that HLA-B7 is associated with the development of breast cancer in our area.
AuthorsRocio Lavado, Manuel Benavides, Esther Villar, Inmaculada Ales, Antonio Alonso, Abelardo Caballero
JournalImmunology letters (Immunol Lett) Vol. 101 Issue 2 Pg. 223-5 (Nov 15 2005) ISSN: 0165-2478 [Print] Netherlands
PMID16188571 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • HLA-B7 Antigen
Topics
  • Alleles
  • Breast Neoplasms (genetics, pathology)
  • Female
  • Genetic Predisposition to Disease (genetics)
  • HLA-B7 Antigen (genetics)
  • Humans
  • Spain

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