Abstract | BACKGROUND: Several HLA alleles are associated with susceptibility or protection in breast cancer. The particular allele varies depending on the geographical region. A study in a small group of Spanish patients using serological methods found an association with HLA-B7. We undertook a larger study in southern Spain using molecular biology techniques. METHODS: Genotype variants of HLA class I and II were typed by PCR-SSP in 132 breast cancer patients and 382 healthy controls. RESULTS: The frequency of the HLA-B7 allele was increased in the patients compared to the controls (P=0.0019; 95% confidence interval, 1.337-3.409, relative risk=2.135). Bonferroni correction of the P showed it was still significant (P(c)=0.0285). CONCLUSIONS: These results support previous suggestions that HLA-B7 is associated with the development of breast cancer in our area.
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Authors | Rocio Lavado, Manuel Benavides, Esther Villar, Inmaculada Ales, Antonio Alonso, Abelardo Caballero |
Journal | Immunology letters
(Immunol Lett)
Vol. 101
Issue 2
Pg. 223-5
(Nov 15 2005)
ISSN: 0165-2478 [Print] Netherlands |
PMID | 16188571
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Alleles
- Breast Neoplasms
(genetics, pathology)
- Female
- Genetic Predisposition to Disease
(genetics)
- HLA-B7 Antigen
(genetics)
- Humans
- Spain
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