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Detection of CD5 in B-cell chronic lymphoproliferative diseases by flow cytometry: a strong expression in B-cell chronic lymphocytic leukemia.

AbstractPURPOSE:
CD5 is a T cell marker, aberrantly express in B cell chronic lymphocytic leukemia (B-CLL) and mantle cell lymphoma (MCL). Other chronic B cell malignancies including hairy cell leukemia (HCL) and B cell prolymphocytic leukemia (B-PLL) are CD5 negative or express this antigen in a weak way. In this study, CD5 expression was investigated in leukemic cells from 42 patients with chronic B cell lymphoproliferative disease.
METHODS:
We studied the CD5 expression in leukemic cells from 42 patients with chronic B-cell malignancies by flow cytometry. Demographic features such as age, sex and clinical date were also analyzed.
RESULTS:
There were 22 males and 20 females. The immunophenotyping showed that 35 cases were B-CLL, 3 B-PLL and HCL and one patient was MCL. CD5 expression was present in all B-CLL and MCL. Low expression of CD5 was observed in one patient with B-PLL and negative in all cases of HCL.
CONCLUSION:
Our date demonstrated that CD5 expression can help distinguish among B-CLL from HCL and B-PLL, but is similar expressed in MCL.
AuthorsGeraldo Barroso Cavalcanti Júnior, Valeria Soraya de Farias Sales, Dany Geraldo Kramer Cavalcanti e Silva, Maria Cleide de Araújo Lopes, Aldair de Souza Paiva, Henrique Eduardo Macedo da Fonseca, Francisco Fernandes do Nascimento Júniors, Maria Zélia Fernandes
JournalActa cirurgica brasileira (Acta Cir Bras) Vol. 20 Suppl 1 Pg. 101-7 ( 2005) ISSN: 0102-8650 [Print] Brazil
PMID16186976 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • CD5 Antigens
Topics
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor (blood)
  • CD5 Antigens (blood)
  • Diagnosis, Differential
  • Female
  • Flow Cytometry (methods)
  • Humans
  • Immunophenotyping
  • Leukemia, Hairy Cell (blood, diagnosis)
  • Leukemia, Lymphocytic, Chronic, B-Cell (blood, diagnosis)
  • Lymphocyte Count
  • Lymphoma, B-Cell (blood, diagnosis)
  • Lymphoma, Mantle-Cell (blood, diagnosis)
  • Lymphoproliferative Disorders (blood, diagnosis)
  • Male
  • Middle Aged

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