Abstract | PURPOSE: METHODS: We studied the CD5 expression in leukemic cells from 42 patients with chronic B-cell malignancies by flow cytometry. Demographic features such as age, sex and clinical date were also analyzed. RESULTS: There were 22 males and 20 females. The immunophenotyping showed that 35 cases were B-CLL, 3 B-PLL and HCL and one patient was MCL. CD5 expression was present in all B-CLL and MCL. Low expression of CD5 was observed in one patient with B-PLL and negative in all cases of HCL. CONCLUSION: Our date demonstrated that CD5 expression can help distinguish among B-CLL from HCL and B-PLL, but is similar expressed in MCL.
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Authors | Geraldo Barroso Cavalcanti Júnior, Valeria Soraya de Farias Sales, Dany Geraldo Kramer Cavalcanti e Silva, Maria Cleide de Araújo Lopes, Aldair de Souza Paiva, Henrique Eduardo Macedo da Fonseca, Francisco Fernandes do Nascimento Júniors, Maria Zélia Fernandes |
Journal | Acta cirurgica brasileira
(Acta Cir Bras)
Vol. 20 Suppl 1
Pg. 101-7
( 2005)
ISSN: 0102-8650 [Print] Brazil |
PMID | 16186976
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers, Tumor
- CD5 Antigens
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Topics |
- Aged
- Aged, 80 and over
- Biomarkers, Tumor
(blood)
- CD5 Antigens
(blood)
- Diagnosis, Differential
- Female
- Flow Cytometry
(methods)
- Humans
- Immunophenotyping
- Leukemia, Hairy Cell
(blood, diagnosis)
- Leukemia, Lymphocytic, Chronic, B-Cell
(blood, diagnosis)
- Lymphocyte Count
- Lymphoma, B-Cell
(blood, diagnosis)
- Lymphoma, Mantle-Cell
(blood, diagnosis)
- Lymphoproliferative Disorders
(blood, diagnosis)
- Male
- Middle Aged
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