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Effects of okchun-san, a herbal formulation, on blood glucose levels and body weight in a model of Type 2 diabetes.

Abstract
The effective control of blood glucose is the key to preventing or reversing diabetic complications. In this study, we examined the effects of Okchun-San (OCS), a Korean herbal medicine formula, on the blood glucose levels in diabetic C57BL/KsJ db/db mice. Herbal medicines were prepared from dried herbs by adding Coicis semen (OCS-C) or Oryzae semen (OCS-O). The experimental animals were divided into a control group and three sample groups; the sample groups received OCS-C (200 mg/kg), OCS-O (200 mg/kg), or acarbose (5 mg/kg) orally once a day for 12 days. On days 5 and 12, the fasting blood glucose levels of vehicle-treated db/db mice were significantly higher than day 0, while those of OCS-C, OCS-O, or acarbose-treated mice had not increased compared to the control group (p<0.01). During intraperitoneal glucose tolerance test (IPGTT), OCS-C group showed improved glucose sensitivity compared to the control group. These results suggest that OCS-C can be useful as an anti-diabetic therapy for Type 2 diabetic patients by lowering the blood glucose level.
AuthorsMun Seog Chang, Myung Sook Oh, Do Rim Kim, Kye Jin Jung, Sunmin Park, Soo Bong Choi, Byoung-Seob Ko, Seong Kyu Park
JournalJournal of ethnopharmacology (J Ethnopharmacol) Vol. 103 Issue 3 Pg. 491-5 (Feb 20 2006) ISSN: 0378-8741 [Print] Ireland
PMID16185833 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Drugs, Chinese Herbal
  • Hypoglycemic Agents
  • okchun-san
  • Acarbose
Topics
  • Acarbose (pharmacology, therapeutic use)
  • Animals
  • Blood Glucose (drug effects)
  • Body Weight (drug effects)
  • Diabetes Mellitus, Type 2 (blood, drug therapy)
  • Disease Models, Animal
  • Drugs, Chinese Herbal (pharmacology, therapeutic use)
  • Glucose Tolerance Test
  • Hypoglycemic Agents (pharmacology, therapeutic use)
  • Mice
  • Mice, Inbred C57BL
  • Time Factors

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