Abstract |
The effective control of blood glucose is the key to preventing or reversing diabetic complications. In this study, we examined the effects of Okchun-San (OCS), a Korean herbal medicine formula, on the blood glucose levels in diabetic C57BL/KsJ db/db mice. Herbal medicines were prepared from dried herbs by adding Coicis semen (OCS-C) or Oryzae semen (OCS-O). The experimental animals were divided into a control group and three sample groups; the sample groups received OCS-C (200 mg/kg), OCS-O (200 mg/kg), or acarbose (5 mg/kg) orally once a day for 12 days. On days 5 and 12, the fasting blood glucose levels of vehicle-treated db/db mice were significantly higher than day 0, while those of OCS-C, OCS-O, or acarbose-treated mice had not increased compared to the control group (p<0.01). During intraperitoneal glucose tolerance test (IPGTT), OCS-C group showed improved glucose sensitivity compared to the control group. These results suggest that OCS-C can be useful as an anti-diabetic therapy for Type 2 diabetic patients by lowering the blood glucose level.
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Authors | Mun Seog Chang, Myung Sook Oh, Do Rim Kim, Kye Jin Jung, Sunmin Park, Soo Bong Choi, Byoung-Seob Ko, Seong Kyu Park |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 103
Issue 3
Pg. 491-5
(Feb 20 2006)
ISSN: 0378-8741 [Print] Ireland |
PMID | 16185833
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Blood Glucose
- Drugs, Chinese Herbal
- Hypoglycemic Agents
- okchun-san
- Acarbose
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Topics |
- Acarbose
(pharmacology, therapeutic use)
- Animals
- Blood Glucose
(drug effects)
- Body Weight
(drug effects)
- Diabetes Mellitus, Type 2
(blood, drug therapy)
- Disease Models, Animal
- Drugs, Chinese Herbal
(pharmacology, therapeutic use)
- Glucose Tolerance Test
- Hypoglycemic Agents
(pharmacology, therapeutic use)
- Mice
- Mice, Inbred C57BL
- Time Factors
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