Abstract |
Human leukocyte antigen (HLA) variations may affect immune response to human papillomavirus infection and subsequent cervical neoplasia risk. We investigated the frequency and relationship between HLA-A-B and HLA-A-B-DR haplotypes among women with cervical cancer/high-grade lesions (n=365) and cytologically normal population controls (n=681) within three cervical neoplasia studies in the US and Costa Rica. Notable differences in haplotype frequencies were observed; the HLA-A*01-B*08 haplotype occurred in >5% of US Caucasians but in <1% of Costa Ricans. The most prevalent HLA-A*24-B*40-DR*04 haplotype in Costa Rica (5%) was found in <1% of US Caucasians. No HLA haplotype was significantly associated with cervical neoplasia, suggesting that individual allele associations reported to date (e.g. HLA-DR*13) are not likely explained by underlying haplotypes.
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Authors | J D Carreon, M P Martin, A Hildesheim, X Gao, M Schiffman, R Herrero, M C Bratti, M E Sherman, R J Zaino, M Carrington, S S Wang |
Journal | Tissue antigens
(Tissue Antigens)
Vol. 66
Issue 4
Pg. 321-4
(Oct 2005)
ISSN: 0001-2815 [Print] England |
PMID | 16185329
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Costa Rica
- Female
- Genetic Predisposition to Disease
(genetics)
- HLA Antigens
(genetics, immunology)
- Haplotypes
(genetics, immunology)
- Humans
- Papillomaviridae
(immunology)
- Papillomavirus Infections
(genetics, immunology)
- Risk Factors
- United States
- Uterine Cervical Neoplasms
(genetics, immunology, virology)
- Uterine Cervical Dysplasia
(genetics, immunology, virology)
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