Long-term remission of blastic natural killer-cell lymphoma after autologous peripheral blood stem-cell transplantation.

We report here a case of blastic natural killer (NK)-cell lymphoma treated successfully with autologous peripheral blood stem-cell transplantation (APBSCT). A 57-year-old man had skin tumors and was diagnosed as having blastic NK-cell lymphoma by tumor biopsy. Skin, lymph nodes, left tonsil, and bone marrow were involved at presentation. Chemotherapy led to complete remission (CR). To sustain CR, the patient underwent high-dose chemotherapy in combination with 12 Gy of total-body irradiation (TBI) followed by autologous peripheral blood stem-cell rescue. He showed rapid recovery of hematopoiesis and could tolerate regimen-related toxicity after APBSCT. He has maintained long-term remission for 20 months after APBSCT. From this case, we concluded that APBSCT with preconditioning by TBI-containing regimens might be a cure-attaining treatment for disseminated blastic NK-cell lymphoma and should be considered as a choice of treatment in cases where no suitable donors for allogeneic transplantation are available.
AuthorsMasaki Yamaguchi, Mio Maekawa, Yoshihisa Nakamura, Mikio Ueda
JournalAmerican journal of hematology (Am J Hematol) Vol. 80 Issue 2 Pg. 124-7 (Oct 2005) ISSN: 0361-8609 [Print] United States
PMID16184583 (Publication Type: Case Reports, Journal Article)
Copyright(c) 2005 Wiley-Liss, Inc.
  • Blast Crisis
  • Hematopoiesis
  • Humans
  • Killer Cells, Natural (pathology)
  • Lymphoma, T-Cell (pathology, therapy)
  • Male
  • Middle Aged
  • Peripheral Blood Stem Cell Transplantation (methods)
  • Remission Induction (methods)
  • Skin Neoplasms
  • Transplantation Conditioning (methods)
  • Transplantation, Autologous
  • Whole-Body Irradiation

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