| Abstract | We report here a case of blastic natural killer (NK)-cell lymphoma treated successfully with autologous peripheral blood stem-cell transplantation (APBSCT). A 57-year-old man had skin tumors and was diagnosed as having blastic NK-cell lymphoma by tumor biopsy. Skin, lymph nodes, left tonsil, and bone marrow were involved at presentation. Chemotherapy led to complete remission (CR). To sustain CR, the patient underwent high-dose chemotherapy in combination with 12 Gy of total-body irradiation (TBI) followed by autologous peripheral blood stem-cell rescue. He showed rapid recovery of hematopoiesis and could tolerate regimen-related toxicity after APBSCT. He has maintained long-term remission for 20 months after APBSCT. From this case, we concluded that APBSCT with preconditioning by TBI-containing regimens might be a cure-attaining treatment for disseminated blastic NK-cell lymphoma and should be considered as a choice of treatment in cases where no suitable donors for allogeneic transplantation are available. |
| Authors | Masaki Yamaguchi, Mio Maekawa, Yoshihisa Nakamura, Mikio Ueda
(Affiliation: Department of Hematology & Immunology, Ishikawa Prefectural Central Hospital, Kanazawa, Japan. myjody at ipch.jp)
|
| Journal | American journal of hematology
(Am J Hematol)
Vol. 80
Issue 2
Pg. 124-7
(Oct 2005)
ISSN: 0361-8609 United States |
| PMID | 16184583
(Publication Type: Case Reports, Journal Article)
|
| Copyright | (c) 2005 Wiley-Liss, Inc. |
| Topics |
- Blast Crisis
- Hematopoiesis
- Humans
- Killer Cells, Natural
(pathology)
- Lymphoma, T-Cell
(pathology, therapy)
- Male
- Middle Aged
- Peripheral Blood Stem Cell Transplantation
(methods)
- Remission Induction
(methods)
- Skin Neoplasms
- Transplantation Conditioning
(methods)
- Transplantation, Autologous
- Whole-Body Irradiation
|
