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Relevance of a rat model of papillary necrosis and upper urothelial carcinoma in understanding the role of ochratoxin A in Balkan endemic nephropathy and its associated carcinoma.

Abstract
Ochratoxin A is nephrotoxic and has been implicated in the genesis of Balkan endemic nephropathy (BEN), a condition that leads to end-stage renal disease and upper urothelial tumours. This compound induces renal parenchymal carcinoma in male mice only, and is not considered to be a potent carcinogen nor is there experimental evidence of its propensity to cause upper urothelial carcinoma. There is, however, evidence that exposure to more than one mycotoxin may be an important factor in the clinical spectrum of BEN. Analgesic nephropathy is clinically different, but is also associated with an upper urothelial carcinoma. The combination of urothelial initiation and an acute papillary necrosis in rats produces upper urothelial carcinoma. This two-stage experimental model offers the potential to assess the role of ochratoxin A in BEN-associated upper urothelial carcinoma under experimental conditions.
AuthorsP H Bach, N J Gregg, L Delacruz
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 30 Issue 3 Pg. 205-11 (Mar 1992) ISSN: 0278-6915 [Print] England
PMID1618444 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Ochratoxins
  • ochratoxin A
Topics
  • Animals
  • Balkan Nephropathy (complications, etiology, physiopathology)
  • Disease Models, Animal
  • Food Contamination
  • Global Health
  • Humans
  • Ochratoxins (toxicity)
  • Rats
  • Urologic Neoplasms (etiology)

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