4,4'-Dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007): a topical treatment for cutaneous metastases from malignant cancers.

Abstract

PURPOSE:

This study is to document the activity and acceptability for a new topical agent, A-007, in the treatment of cutaneous metastases from cancer.

PATIENTS AND METHODS:

This is a multicenter study involving 27 patients with inoperable skin lesions from histologically confirmed cancers of the breast and oral cavity, non-Hodgkin's lymphoma, Kaposi's sarcoma, and angiosarcoma that had failed radiotherapy or systemic treatment. A-007, as a 0.25% gel, was applied twice daily to the areas of cancer to be measured as well as applied to a healthy control area distant from the cancer areas. An untreated cancer area was also included and documented as a cancer control.

RESULTS:

The overall objected response rate with A-007 was 26%, with an additional 19% minimum response/stabilization of cancer. For patients with breast cancer, hormonal status did not have an impact on response. The median duration of response was 15 weeks (with one patient having a response for 3.5 years). Toxicities observed were itching, burning, and a rash, in 6 of the 27 patients. The skin toxicities were in the cancer-treated fields; none were observed in the A-007 control areas. All irritated areas cleared while continuing treatment, and the tumor lesions in the areas of itching also improved.

CONCLUSION:

A-007, as a 0.25% gel, is confirmed as an effective palliative treatment option for cutaneous metastases from cancers. Skin reactions were minimal, tolerated, and no cessation of treatment was required.

• Authors: David Eilender, Patricia LoRusso, Leonard Thomas, Catherine McCormick, Andrew H Rodgers, Catherine L Hooper, Karl Tornyos, Edward T Krementz, Steven Parker, Lee Roy Morgan
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 57 Issue 6 Pg. 719-26 (Jun 2006) ISSN: 0344-5704 [Print] Germany
• PMID: 16184382 (Publication Type: Clinical Trial, Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone
• Antineoplastic Agents
• Hydrazones
• Phenols

Topics

• Administration, Topical
• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents (adverse effects, pharmacokinetics, therapeutic use)
• Female
• Humans
• Hydrazones (adverse effects, pharmacokinetics, therapeutic use)
• Male
• Middle Aged
• Multicenter Studies as Topic
• Phenols (adverse effects, pharmacokinetics, therapeutic use)
• Skin Neoplasms (drug therapy, metabolism, secondary)