[Influence of the expression of heat shock protein 70 in maxillofacial squamous cell carcinoma by thermochemotherapy].

Abstract

OBJECTIVE:

To study the influence of thermochemotheraphy on the expression of HSP70 in maxillofacial squamous cell carcinoma.

METHODS:

12 patients were treated with thermochemotheraphy twice a week, altogether 10 times. After 8 mg of Pingyangmycin infused, the patients were treated with microwave hyperthermia at 43 degrees C for 40 min. The part of carcinoma tissue was removed with surgical operations at before treatment and aftre five times of treatment. The expression of HSP70 in tumor cells was determined by SP immunohistochemcial method.

RESULTS:

The expression of HSP70 in tumor cells was enhanced obviously by thermochemotherapy.

CONCLUSION:

Special high expression of HSP70 in the tumor cells was induced by thermochemotherapy. With the antigen presenting action and other action, HSP70 have special antitumor effect.

• Authors: Sheng-Zhi Wang, Li Wang, Xiang-Dong Gao, Zhou Cheng, Hong-Guang Bi, Da-Zhang Wang
• Journal: Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology (Hua Xi Kou Qiang Yi Xue Za Zhi) Vol. 23 Issue 4 Pg. 277-9 (Aug 2005) ISSN: 1000-1182 [Print] China
• PMID: 16178182 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HSP70 Heat-Shock Proteins

Topics

• Carcinoma, Squamous Cell
• HSP70 Heat-Shock Proteins
• Humans