[Therapeutic effects of cefepime and sulbactam/cefoperazone on moderate and severe respiratory tract infection in children].

Abstract

OBJECTIVE:

To evaluate the therapeutic effects and safety of cefepime (Maxipime) and sulbactam/cefoperazone (sulperazone) on moderate and severe respiratory infection in children.

METHODS:

Totally 100 children hospitalized for pneumonia were randomized equally into 2 groups, namely group A with maxipime treatment at the dose of 50 mg/kg given intravenously twice daily, and group B with sulperazone treatment at 50-100 mg/kg given intravenously twice a day. The therapeutic effects and safety of both medications were observed.

RESULTS:

In maxipime group, 44 of the 50 cases were cured with complete elimination of the symptoms and signs, and obvious therapeutic effect was achieved in 5 cases with significant improvement or resolution of the majority of symptoms and signs. One case failed to respond favorably to the treatment, with the overall efficacy rate of 98% without incidence of adverse effects. In sulperazone group, 40 of the 50 cases were cured, 6 showed significant improvement, and 4 failed to respond to the treatment, with the rate of 92%. One patient complained of rashes during sulperazone treatment, which disappeared the next day without sulperazone withdrawal. Significant difference was not noted between the groups (chi(2)=2.43, P>0.05).

CONCLUSIONS:

Both maxipime and sulperazon are effective and safe for application in children with moderate and severe respiratory infections.

• Authors: Jian-jun Huang, Qiang Zeng, Jia-lu Yu
• Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA (Di Yi Jun Yi Da Xue Xue Bao) Vol. 25 Issue 9 Pg. 1199-200 (Sep 2005) ISSN: 1000-2588 [Print] China
• PMID: 16174597 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Cephalosporins
• Cefoperazone
• Cefepime
• Sulbactam

Topics

• Anti-Bacterial Agents (therapeutic use)
• Cefepime
• Cefoperazone (administration & dosage, therapeutic use)
• Cephalosporins (therapeutic use)
• Child
• Child, Preschool
• Drug Therapy, Combination
• Female
• Humans
• Infant
• Male
• Pneumonia, Bacterial (drug therapy)
• Sulbactam (administration & dosage, therapeutic use)