[A study about the association of detoxication gene GSTM1 polymorphism and the susceptibility to aflatoxin B1-related hepatocellular carcinoma].

Abstract

OBJECTIVES:

To investigate the association between susceptibility to aflatoxin B1(AFB1)-related hepatocellular carcinoma (HCC) and the polymorphism of detoxication gene GSTM1.

METHODS:

The peripheral white blood cell DNA samples were obtained from all the subjects including 140 HCC cases and 536 controls from an AFB1 high risk area in Guangxi province. The GSTM1 polymorphism was detected using PCR technique.

RESULTS:

(1) The GSTM1-present was associated with a decreased HCC risk. The GSTM1-null was associated with an increased HCC risk [adjusted OR (95% CI)= 2.07 (1.20-3.57)]. (2) In the cohorts of both low/median and high exposure levels of AFB1, GSTM1-null genotype was associated with a conspicuous significantly increased risk for HCC [adjusted OR (95% CI) = 1.92 (0.92-4.00) and 1.80 (0.77-4.17)].

CONCLUSION:

The results suggest that genetic polymorphism of GSTM1 was susceptible to HCC and individuals who are GSTM1-null have an increased risk of developing HCC. There is evidence of interaction between GSTM1 polymorphism and AFB1 exposure, especially with low/median degrees of AFB1 exposure.

• Authors: Xi-dai Long, Yun Ma, Yi-ping Wei, Zhuo-lin Deng
• Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology (Zhonghua Gan Zang Bing Za Zhi) Vol. 13 Issue 9 Pg. 668-70 (Sep 2005) ISSN: 1007-3418 [Print] China
• PMID: 16174455 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Aflatoxin B1
• Glutathione Transferase
• glutathione S-transferase M1

Topics

• Aflatoxin B1 (genetics)
• Carcinoma, Hepatocellular (genetics)
• Genetic Predisposition to Disease
• Glutathione Transferase (genetics)
• Humans
• Liver Neoplasms (genetics)
• Polymorphism, Genetic