[Analysis of group B streptococcal gene scaAB encoding the protein involved in adherence and aggregation].

Abstract

The portion of group B streptococcal (GBS) sequence encoding the ABC transport system was cloned and sequenced. The genetic region under study included scaAB gene, which was capable of encoding for putative adherence and aggregation factor, and scaR, which was encoding for putative represser. After the insertional inactivation of scaAB gene on the GBS chromosome streptococci increased the tendency for aggregation. The level of GBS adherence to vaginal epithelium was also different after scaAB inactivation. GBS sea operon was compared to similar ABC encoding bacterial operons.

• Authors: E I Vorob'eva, O V Vorob'eva, A N Suvorova
• Journal: Molekuliarnaia genetika, mikrobiologiia i virusologiia (Mol Gen Mikrobiol Virusol) Issue 3 Pg. 9-11 ( 2005) ISSN: 0208-0613 [Print] Russia (Federation)
• PMID: 16173392 (Publication Type: English Abstract, Journal Article)

Chemical References

• Adhesins, Bacterial
• Bacterial Proteins

Topics

• Adhesins, Bacterial (genetics)
• Bacterial Adhesion
• Bacterial Proteins (genetics)
• Cloning, Molecular
• Epithelium (microbiology)
• Female
• Genes, Bacterial
• Humans
• Mutagenesis, Insertional
• Sequence Analysis, DNA
• Streptococcus agalactiae (genetics, pathogenicity)
• Vagina (cytology)
• Virulence (genetics)