New approach of the treatment of von Willebrand's disease during pregnancy.

Abstract

AIM:

The aim of the study was to analyze the effectiveness of the application of DDAVP (desmopressin) and Hemate P with cryoprecipitate pre- and postpartum in patients with von Willebrand disease.

METHODS:

We monitored 32 patients with von Willebrand disease during the study period 1993-2003. DDAVP was applied in the 36th/37th week of gestation and cryoprecipitate and fresh frozen plasma were applied 1 day before and 3 days after delivery. DDAVP treatment continued for 4 weeks. Factor VIII (Hemate P) at the day of delivery

RESULTS:

No complications occurred in the studied population.

CONCLUSION:

Precipitation of DDAVP, Hemate P, and cryoprecipitate may help in the treatment of pregnant women with von Willebrand disease.

• Authors: Miroslava Gojnic, A Fazlagic, I Likic, A Stefanovic, S Vidakovic, M Pervulov, S Petkovic, T Mostic, P Miljic, A Bogdanovic
• Journal: Archives of gynecology and obstetrics (Arch Gynecol Obstet) Vol. 273 Issue 1 Pg. 35-8 (Nov 2005) ISSN: 0932-0067 [Print] Germany
• PMID: 16172853 (Publication Type: Journal Article)

Chemical References

• Hemostatics
• cryoprecipitate coagulum
• Factor VIII
• Fibrinogen
• Deamino Arginine Vasopressin

Topics

• Deamino Arginine Vasopressin (administration & dosage)
• Delivery, Obstetric (methods)
• Factor VIII (administration & dosage, analysis)
• Female
• Fibrinogen (administration & dosage, analysis)
• Gestational Age
• Hemostatics (administration & dosage)
• Humans
• Partial Thromboplastin Time
• Postpartum Period
• Pregnancy
• Pregnancy Complications, Hematologic (drug therapy, therapy)
• Prothrombin Time
• von Willebrand Diseases (blood, drug therapy, therapy)