Abstract |
Considerable rodent strain differences have been documented with regard to susceptibility to colon carcinogens. To clarify mechanisms, chimeras of susceptible strain C3H and relatively resistant strain C57BL/6N (B6) mice were exposed to a colonotropic carcinogen, 1,2-dimethylhydrazine ( DMH) and tumor incidence and multiplicity were assessed. In the chimeras, incidence was as high as the C3H level. Multiplicity of lesions of B6 cells was also increased (P<0.001), but maintenance of the strain difference. When tumor localization was analyzed, tumors of B6 genotype in chimeras demonstrated a greater spread of distribution than in the parental case. The chimeric environment may thus stimulate tumor initiation but cell autonomous suppressive factors may be retained.
|
Authors | Tetsuya Tsukamoto, Masami Yamamoto, Hiroko Fukami, Akemi Yoshikawa, Hiroki Sakai, Akihiro Hirata, Moriaki Kusakabe, Masae Tatematsu |
Journal | Cancer letters
(Cancer Lett)
Vol. 239
Issue 2
Pg. 205-11
(Aug 08 2006)
ISSN: 0304-3835 [Print] Ireland |
PMID | 16168562
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Topics |
- Animals
- Chimera
- Colonic Neoplasms
(genetics, pathology)
- Disease Susceptibility
- Genotype
- Immunohistochemistry
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
|