Antibiotic dosing in critically ill adult patients receiving continuous renal replacement therapy.

Abstract

Continuous renal replacement therapy (CRRT) is now commonly used as a means of support for critically ill patients with renal failure. No recent comprehensive guidelines exist that provide antibiotic dosing recommendations for adult patients receiving CRRT. Doses used in intermittent hemodialysis cannot be directly applied to these patients, and antibiotic pharmacokinetics are different than those in patients with normal renal function. We reviewed the literature for studies involving the following antibiotics frequently used to treat critically ill adult patients receiving CRRT: vancomycin, linezolid, daptomycin, meropenem, imipenem-cilastatin, nafcillin, ampicillin-sulbactam, piperacillin-tazobactam, ticarcillin-clavulanic acid, cefazolin, cefotaxime, ceftriaxone, ceftazidime, cefepime, aztreonam, ciprofloxacin, levofloxacin, moxifloxacin, clindamycin, colistin, amikacin, gentamicin, tobramycin, fluconazole, itraconazole, voriconazole, amphotericin B (deoxycholate and lipid formulations), and acyclovir. We used these data, as well as clinical experience, to make recommendations for antibiotic dosing in critically ill patients receiving CRRT.

• Authors: Robin L Trotman, John C Williamson, D Matthew Shoemaker, William L Salzer
• Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 41 Issue 8 Pg. 1159-66 (Oct 15 2005) ISSN: 1537-6591 [Electronic] United States
• PMID: 16163635 (Publication Type: Journal Article, Review)

Chemical References

• Anti-Bacterial Agents
• Antifungal Agents

Topics

• Anti-Bacterial Agents (administration & dosage)
• Antifungal Agents (administration & dosage)
• Critical Illness (therapy)
• Humans
• Renal Insufficiency (therapy)
• Renal Replacement Therapy